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Issue 6, 2013

Copper(i)-catalyzed diastereoselective hydroxytrifluoromethylation of dienes accelerated by phosphine ligands

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Abstract

A diastereoselective 1,4-hydroxytrifluoromethylation of dienes is catalyzed by copper cyanide–phosphine complexes. This reaction is significantly accelerated by bulky monodentate phosphines, and the discovery enables expedient access to a variety of CF3-containing allylic alcohol derivatives.

Graphical abstract: Copper(i)-catalyzed diastereoselective hydroxytrifluoromethylation of dienes accelerated by phosphine ligands

Supplementary files

Article information


Submitted
28 Feb 2013
Accepted
19 Mar 2013
First published
20 Mar 2013

Chem. Sci., 2013,4, 2478-2482
Article type
Edge Article

Copper(I)-catalyzed diastereoselective hydroxytrifluoromethylation of dienes accelerated by phosphine ligands

D. Lu, C. Zhu and H. Xu, Chem. Sci., 2013, 4, 2478 DOI: 10.1039/C3SC50582K

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