Issue 10, 2013
From the journal:

Chemical Science

Radical carbooxygenations of alkenes using hydroxamic acids†

Ryan K. Quinn,a   Valerie A. Schmidta  and  Erik J. Alexanian*a  

* Corresponding authors

a Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
E-mail: eja@email.unc.edu

Abstract

A radical-mediated approach to alkene carbooxygenation using hydroxamic acids is described. These transformations represent rare examples of direct carbooxygenations, and deliver versatile functionality to the unsaturated substrate. Included in this study are alkene oxyallylation, oxycyanation, and formal oxyacylation processes. These unique reactions capitalize on the reactivity of amidoxyl radicals in alkene additions.

Graphical abstract: Radical carbooxygenations of alkenes using hydroxamic acids

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Article information

DOI
https://doi.org/10.1039/C3SC51466H
Article type
Edge Article
Submitted
24 May 2013
Accepted
17 Jul 2013
First published
19 Jul 2013

Chem. Sci., 2013,4, 4030-4034

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Radical carbooxygenations of alkenes using hydroxamic acids

R. K. Quinn, V. A. Schmidt and E. J. Alexanian, Chem. Sci., 2013, 4, 4030 DOI: 10.1039/C3SC51466H

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