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Issue 8, 2013
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Synthetically defined glycoprotein vaccines: current status and future directions

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Abstract

Primary examples in vaccine design have shown good levels of carbohydrate-specific antibody generation when raised using extracted or fully synthetic capsular polysaccharide glycans covalently coupled to a protein carrier. Herein, we cover recent clinical developments of carbohydrate-based vaccines and describe how novel cutting-edge methodology for the total synthesis of oligosaccharides and for the precise placement of carbohydrates at pre-determined sites within a protein may be used to further improve the safety and efficacy of glycovaccines.

Graphical abstract: Synthetically defined glycoprotein vaccines: current status and future directions

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Article information


Submitted
30 Mar 2013
Accepted
03 May 2013
First published
07 May 2013

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2013,4, 2995-3008
Article type
Perspective

Synthetically defined glycoprotein vaccines: current status and future directions

R. Adamo, A. Nilo, B. Castagner, O. Boutureira, F. Berti and G. J. L. Bernardes, Chem. Sci., 2013, 4, 2995
DOI: 10.1039/C3SC50862E

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