Issue 5, 2013
From the journal:

Chemical Science

Pd-catalyzed oxidative C–H/C–H cross-coupling of pyridines with heteroarenes†

Bo Liu,a   Yumin Huang,a   Jingbo Lan,a   Feijie Songa  and  Jingsong You*a  

* Corresponding authors

a Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China
E-mail: jsyou@scu.edu.cn
Fax: +86 28-85412203
Tel: +86 28-85412203

Abstract

We have developed for the first time a general, concise and highly selective method for the C2-heteroarylation of pyridines and related azines with a broad range of heteroarenes via a two-fold C–H activation, which streamlines the previous approaches that require the activated azine N-oxide as the coupling partner.

Graphical abstract: Pd-catalyzed oxidative C–H/C–H cross-coupling of pyridines with heteroarenes

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Article information

DOI
https://doi.org/10.1039/C3SC50348H
Article type
Edge Article
Submitted
04 Dec 2012
Accepted
21 Feb 2013
First published
22 Feb 2013

Chem. Sci., 2013,4, 2163-2167

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Pd-catalyzed oxidative C–H/C–H cross-coupling of pyridines with heteroarenes

B. Liu, Y. Huang, J. Lan, F. Song and J. You, Chem. Sci., 2013, 4, 2163 DOI: 10.1039/C3SC50348H

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