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Issue 5, 2013
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DNA-based asymmetric organometallic catalysis in water

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Abstract

Here, the first examples of DNA-based organometallic catalysis in water that give rise to high enantioselectivities are described. Copper complexes of strongly intercalating ligands were found to enable the asymmetric intramolecular cyclopropanation of α-diazo-β-keto sulfones in water. Up to 84% ee was achieved, in the presence of salmon testes DNA as the only source of chirality, using dipyrido[3,2-a:2′,3′-c]phenazine (dppz) derivatives as ligands.

Graphical abstract: DNA-based asymmetric organometallic catalysis in water

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Article information


Submitted
11 Jan 2013
Accepted
15 Mar 2013
First published
15 Mar 2013

Chem. Sci., 2013,4, 2013-2017
Article type
Edge Article

DNA-based asymmetric organometallic catalysis in water

J. Oelerich and G. Roelfes, Chem. Sci., 2013, 4, 2013
DOI: 10.1039/C3SC00100H

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