Jump to main content
Jump to site search

Issue 3, 2013
Previous Article Next Article

A visible-light-promoted aerobic C–H/C–N cleavage cascade to isoxazolidine skeletons

Author affiliations

Abstract

The bicyclic isoxazolidine scaffolds are the ubiquitously recurring motifs in alkaloids. Despite of their facile biosynthesises in nature, the laboratory synthesis of these derivatives is still complicated. In this paper, the isoxazolidine derivatives are concisely constructed in one process with excellent stereoselectivity from simple tertiary amines through a C–H activation-retro-aza-Michael-oxidation-cyclization tandem sequence by means of visible-light. This protocol provides a concise approach to dactylicapnosinine derivatives.

Graphical abstract: A visible-light-promoted aerobic C–H/C–N cleavage cascade to isoxazolidine skeletons

Back to tab navigation

Supplementary files

Article information


Submitted
03 Dec 2012
Accepted
03 Jan 2013
First published
04 Jan 2013

Chem. Sci., 2013,4, 1281-1286
Article type
Edge Article

A visible-light-promoted aerobic C–H/C–N cleavage cascade to isoxazolidine skeletons

J. Xie, Q. Xue, H. Jin, H. Li, Y. Cheng and C. Zhu, Chem. Sci., 2013, 4, 1281
DOI: 10.1039/C2SC22131D

Social activity

Search articles by author

Spotlight

Advertisements