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Issue 37, 2013
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Phosphorus oxychloride as an efficient coupling reagent for the synthesis of esters, amides and peptides under mild conditions

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Abstract

A mild method is described for the conversion of carboxylic acids into esters, amides, as well as peptides without racemization through carboxyl activation by the reagent combination of POCl3 and DMAP. Long chain alcohols could be converted to the corresponding ester in good yields. 31P NMR spectrum was used to detect phosphorus-containing intermediates in ongoing reactions directly, and a possible mechanism has been proposed based on these results.

Graphical abstract: Phosphorus oxychloride as an efficient coupling reagent for the synthesis of esters, amides and peptides under mild conditions

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Publication details

The article was received on 11 Jun 2013, accepted on 12 Jul 2013 and first published on 12 Jul 2013


Article type: Communication
DOI: 10.1039/C3RA42887G
Citation: RSC Adv., 2013,3, 16247-16250
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    Phosphorus oxychloride as an efficient coupling reagent for the synthesis of esters, amides and peptides under mild conditions

    H. Chen, X. Xu, L. Liu, G. Tang and Y. Zhao, RSC Adv., 2013, 3, 16247
    DOI: 10.1039/C3RA42887G

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