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Issue 35, 2013
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An ab initio explanation of the activation and antagonism strength of an AMPA-sensitive glutamate receptor

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Abstract

We report quantum biochemistry calculations focusing on the binding pocket of the glutamate receptor co-crystallized with agonists (full and partial) and a antagonist. The calculated electronic binding energy follows the order AMPA > glutamate > kainate > DNQX, which explains published experimental data on GluR2 activation and antagonism strength.

Graphical abstract: An ab initio explanation of the activation and antagonism strength of an AMPA-sensitive glutamate receptor

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Publication details

The article was received on 01 May 2013, accepted on 20 Jul 2013 and first published on 22 Jul 2013


Article type: Communication
DOI: 10.1039/C3RA42149J
Citation: RSC Adv., 2013,3, 14988-14992
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    An ab initio explanation of the activation and antagonism strength of an AMPA-sensitive glutamate receptor

    A. C. V. Martins, P. de Lima-Neto, I. L. Barroso-Neto, B. S. Cavada, V. N. Freire and E. W. S. Caetano, RSC Adv., 2013, 3, 14988
    DOI: 10.1039/C3RA42149J

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