Issue 35, 2013
From the journal:

RSC Advances

An ab initio explanation of the activation and antagonism strength of an AMPA-sensitive glutamate receptor

Ana Caroline V. Martins,*a   Pedro de Lima-Neto,a   Ito L. Barroso-Neto,b   Benildo S. Cavada,b   Valder N. Freirec  and  Ewerton W. S. Caetanod  

* Corresponding authors

a Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará, Campus do Pici, 60455-760 Fortaleza, Ceará, Brazil
E-mail: carolinevmartins@gmail.com, plimaneto@gmail.com

b Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Campus do Pici, 60410-970 Fortaleza, Ceará, Brazil
E-mail: itoliberato@gmail.com, bscavada@gmail.com

c Departamento de Física, Universidade Federal do Ceará, Centro de Ciências, CP 6030, Campus do Pici, 60455-760 Fortaleza, Ceará, Brazil
E-mail: vnffreire@gmail.com

d Instituto de Educação, Ciência e Tecnologia do Ceará, 60040-531 Fortaleza, Ceará, Brazil
E-mail: ewcaetano@gmail.com

Abstract

We report quantum biochemistry calculations focusing on the binding pocket of the glutamate receptor co-crystallized with agonists (full and partial) and a antagonist. The calculated electronic binding energy follows the order AMPA > glutamate > kainate > DNQX, which explains published experimental data on GluR2 activation and antagonism strength.

Graphical abstract: An ab initio explanation of the activation and antagonism strength of an AMPA-sensitive glutamate receptor

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Article information

DOI
https://doi.org/10.1039/C3RA42149J
Article type
Communication
Submitted
01 May 2013
Accepted
20 Jul 2013
First published
22 Jul 2013

RSC Adv., 2013,3, 14988-14992

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An ab initio explanation of the activation and antagonism strength of an AMPA-sensitive glutamate receptor

A. C. V. Martins, P. de Lima-Neto, I. L. Barroso-Neto, B. S. Cavada, V. N. Freire and E. W. S. Caetano, RSC Adv., 2013, 3, 14988 DOI: 10.1039/C3RA42149J

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