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Issue 17, 2013
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Ruthenium-catalyzed one-pot synthesis of primary amides from aldehydes in water

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Abstract

The readily available arene–ruthenium(II) complex [RuCl26-C6Me6){P(NMe2)3}] (5 mol%) proved to be an efficient catalyst for the direct synthesis of primary amides from aldehydes and hydroxylamine hydrochloride (NH2OH·HCl) in water at 100 °C. The process, which requires the presence of NaHCO3 to catch the HCl released during the formation of the key aldoxime intermediates, was operative with both aromatic, heteroaromatic, α,β-unsaturated and aliphatic aldehydes, and tolerated several functional groups. A greener approach using commercially available NH2OH solution (50 wt.% in water) is also presented.

Graphical abstract: Ruthenium-catalyzed one-pot synthesis of primary amides from aldehydes in water

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Publication details

The article was received on 05 Dec 2012, accepted on 05 Feb 2013 and first published on 06 Feb 2013


Article type: Paper
DOI: 10.1039/C3RA23195J
RSC Adv., 2013,3, 5889-5894

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    Ruthenium-catalyzed one-pot synthesis of primary amides from aldehydes in water

    R. García-Álvarez, A. E. Díaz-Álvarez, P. Crochet and V. Cadierno, RSC Adv., 2013, 3, 5889
    DOI: 10.1039/C3RA23195J

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