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Issue 22, 2013
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Fundamentals and electrochemical applications of [Ni–Fe]-uptake hydrogenases

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Abstract

Hydrogenases are found in a wide range of archaea, prokaryotes and eukaryotes as soluble and membrane-bound enzymes and are generally classified by the structure of the catalytic site. From a biotechnological perspective, hydrogenases have been examined for their role in the production of biohydrogen; for co-factor regeneration in coupled enzyme reactions; for environmental applications, and for the electrochemical oxidation of molecular hydrogen. Hydrogenases, with their ability to readily oxidise hydrogen or reduce protons into hydrogen, have huge potential as biocatalysts in many emerging technologies based on the use of hydrogen as a clean energy vector. This review will focus on the hydrogenases associated with the oxidation of molecular hydrogen (so-called “uptake hydrogenases” (EC 1.12.99.6)), covering their properties, structure, isolation, and remaining barriers for potential industrial applications, including bio-fuel cells, photocatalytic water splitting and hydrogen sensors.

Graphical abstract: Fundamentals and electrochemical applications of [Ni–Fe]-uptake hydrogenases

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Publication details

The article was received on 29 Oct 2012, accepted on 25 Jan 2013 and first published on 28 Jan 2013


Article type: Review Article
DOI: 10.1039/C3RA22668A
Citation: RSC Adv., 2013,3, 8142-8159
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    Fundamentals and electrochemical applications of [Ni–Fe]-uptake hydrogenases

    B. Jugder, J. Welch, K. Aguey-Zinsou and C. P. Marquis, RSC Adv., 2013, 3, 8142
    DOI: 10.1039/C3RA22668A

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