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Issue 12, 2013
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Regioselective [5 + 1] rearrangement–annulation: a new and efficient domino route to highly functionalized [1,6]naphthyridines

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Abstract

A new [5 + 1] rearrangement–annulation for the regioselective formation of polyfunctionalized [1,6]naphthyridines is described. The new construction of a pyridin-2(1H)-one skeleton and its alkylation on the pyridin-2(1H)-one unit were readily achieved through a novel sequential [4 + 2] cyclization–ring opening–intramolecular cyclization–re-cyclization–elimination of urea process.

Graphical abstract: Regioselective [5 + 1] rearrangement–annulation: a new and efficient domino route to highly functionalized [1,6]naphthyridines

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Publication details

The article was received on 27 Sep 2012, accepted on 28 Jan 2013 and first published on 05 Feb 2013


Article type: Communication
DOI: 10.1039/C3RA22328K
Citation: RSC Adv., 2013,3, 3877-3880
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    Regioselective [5 + 1] rearrangement–annulation: a new and efficient domino route to highly functionalized [1,6]naphthyridines

    M. Tu, Y. Li, X. Wang, B. Jiang, S. Wang and S. Tu, RSC Adv., 2013, 3, 3877
    DOI: 10.1039/C3RA22328K

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