Jump to main content
Jump to site search

Issue 11, 2013
Previous Article Next Article

New clicked full agonists of the estrogen receptor β

Author affiliations

Abstract

A click chemistry approach was used to synthesize a series of 1,4-diaryl-substituted 1,2,3-triazoles designed to behave as estrogen receptor (ER) ligands. We studied their affinities for both receptors α and β, their agonist activities in a cell-based luciferase reporter assay and their effect on the proliferation of the hormone-dependent MCF-7 cell line. We found two compounds (3a and 3c) that behave as selective full agonists for ERβ at a 20 μM concentration, and one of them (3c) showed no proliferative effect on MCF-7 cells.

Graphical abstract: New clicked full agonists of the estrogen receptor β

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Jan 2013, accepted on 10 Jan 2013 and first published on 11 Jan 2013


Article type: Paper
DOI: 10.1039/C3RA00122A
RSC Adv., 2013,3, 3697-3706

  •   Request permissions

    New clicked full agonists of the estrogen receptor β

    S. Demkowicz, K. Filipiak, M. Maslyk, J. Ciepielski, S. de Pascual-Teresa, S. Martín-Santamaría, B. D. Pascual-Teresa and A. Ramos, RSC Adv., 2013, 3, 3697
    DOI: 10.1039/C3RA00122A

Search articles by author

Spotlight

Advertisements