Issue 47, 2013

Concise asymmetric synthesis of Linezolid through catalyzed Henry reaction

Abstract

A new asymmetric synthesis of the antibiotic Linezolid was performed through a copper-catalyzed Henry reaction as the key step. The use of camphor-derived aminopyridine ligands helped to improve the yields of the chiral precursor and to obtain Linezolid in good overall yield and enantiomeric excess.

Graphical abstract: Concise asymmetric synthesis of Linezolid through catalyzed Henry reaction

Supplementary files

Article information

Article type
Paper
Submitted
17 Sep 2013
Accepted
18 Oct 2013
First published
21 Oct 2013

RSC Adv., 2013,3, 24946-24951

Concise asymmetric synthesis of Linezolid through catalyzed Henry reaction

A. P. Piccionello, P. Pierro, A. Accardo, S. Buscemi and A. Pace, RSC Adv., 2013, 3, 24946 DOI: 10.1039/C3RA45186K

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