Copper(ii) triflate-catalyzed reactions for the synthesis of novel and diverse quinoline carboxylates

Abstract

An efficient one-pot synthesis of a variety of quinoline carboxylates was accomplished by Cu(OTf)₂-catalyzed reactions of Michael addition/cyclization/aromatization between 2-aminoaryl carbonyls and alkynyl carboxylates. This methodology offers several significant advantages, namely, ease of handling, mild reaction conditions, enhanced reaction rates, and use of an effective and non-toxic catalyst. The synthesized compounds were further transformed into highly functionalized novel quinoline carboxylates bearing aromatic rings on the quinoline skeleton using the Suzuki reaction.