Diastereoselective synthesis of polysubstituted Δ1-pyrroline derivatives from in situ generated nitrile ylides

Zhi-Wei Guo; Xiao Huang; Jia-Min Mao; Wei-Dong Zhu; Jian-Wu Xie

doi:10.1039/C3RA44736G

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Diastereoselective synthesis of polysubstituted Δ¹-pyrroline derivatives from in situ generated nitrile ylides†

Zhi-Wei Guo,^a Xiao Huang,^a Jia-Min Mao,^a Wei-Dong Zhu^a and Jian-Wu Xie*^a

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* Corresponding authors

^a Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Department of Chemistry and Life Science, Zhejiang Normal University, Jinhua 321004, China
E-mail: xiejw@zjnu.cn
Fax: +86 579 82282610

Abstract

An effective strategy has been developed for the rapid synthesis of Δ¹-pyrroline derivatives from readily available α,β-unsaturated ketones and benzamides. This strategy allows access to a structurally diverse array of products for further manipulation.

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Article information

DOI: https://doi.org/10.1039/C3RA44736G
Article type: Paper
Submitted: 29 Aug 2013
Accepted: 14 Oct 2013
First published: 16 Oct 2013

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RSC Adv., 2013,3, 25103-25109

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Diastereoselective synthesis of polysubstituted Δ¹-pyrroline derivatives from in situ generated nitrile ylides

Z. Guo, X. Huang, J. Mao, W. Zhu and J. Xie, RSC Adv., 2013, 3, 25103 DOI: 10.1039/C3RA44736G

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