Issue 47, 2013
From the journal:

RSC Advances

Synthesis of [18F]4-(4-fluorophenyl)-1,2,4-triazole-3,5-dione: an agent for specific radiolabelling of tyrosine

Flagothier Jessica,*ab   Warnier Corentin,b   Dammicco Sylvestre,ab   Lemaire Christianb  and  Luxen Andréab  

* Corresponding authors

a Département de chimie, Université de Liège, 3 allée du 6 aout, B-4000 Liège, Belgium
E-mail: jflagothier@ulg.ac.be
Fax: +32 4 3662946
Tel: +32 4 3662334

b Centre de Recherches du Cyclotron, Université de Liège, 8 allée du 6 aout, B-4000 Liège, Belgium
E-mail: aluxen@ulg.ac.be
Fax: +32 4 3662946
Tel: +32 4 3663687

Abstract

We developed a new [18F] prosthetic group, the [18F]4-(4-fluorophenyl)-1,2,4-triazole-3,5-dione ([18F]F-PTAD), used for its specific ligation with tyrosine-containing peptides or protein in order to develop a new and versatile radiolabelling technique that could provide a useful tool for new developments in PET imaging.

Graphical abstract: Synthesis of [18F]4-(4-fluorophenyl)-1,2,4-triazole-3,5-dione: an agent for specific radiolabelling of tyrosine

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Article information

DOI
https://doi.org/10.1039/C3RA44666B
Article type
Paper
Submitted
26 Aug 2013
Accepted
10 Oct 2013
First published
14 Oct 2013

RSC Adv., 2013,3, 24936-24940

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Synthesis of [18F]4-(4-fluorophenyl)-1,2,4-triazole-3,5-dione: an agent for specific radiolabelling of tyrosine

F. Jessica, W. Corentin, D. Sylvestre, L. Christian and L. André, RSC Adv., 2013, 3, 24936 DOI: 10.1039/C3RA44666B

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