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Issue 44, 2013
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A catalyst-free system for 3-sulfenylation of free (NH) indoles with mercaptobenzoic acid under alkaline conditions

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Abstract

We have developed a catalyst-free system for the 3-sulfenylation of free (NH) indoles using mercaptobenzoic acid under alkaline conditions. The use of this system provides a green, convenient, and efficient method for the synthesis of 3-sulfenylindoles in good yields and with high selectivity. This simple synthesis process was carried out in a green solvent, isopropanol/H2O, under atmospheric and catalyst-free conditions. The procedure is suitable for use with N-unprotected indoles.

Graphical abstract: A catalyst-free system for 3-sulfenylation of free (N–H) indoles with mercaptobenzoic acid under alkaline conditions

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Publication details

The article was received on 20 Aug 2013, accepted on 23 Sep 2013 and first published on 02 Oct 2013


Article type: Paper
DOI: 10.1039/C3RA44484H
RSC Adv., 2013,3, 22280-22284

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    A catalyst-free system for 3-sulfenylation of free (NH) indoles with mercaptobenzoic acid under alkaline conditions

    X. Zhang, X. Zhou, H. Xiao and X. Li, RSC Adv., 2013, 3, 22280
    DOI: 10.1039/C3RA44484H

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