A quick and flexible synthetic approach to enureas (alkenyl ureas) via the Pd-catalyzed C–N coupling reaction of alkenyl tosylates and mesylates

Abstract

As part of our persistent exploration to elucidate the chemistry of Pd-catalyzed C–N coupling, a catalyst system for the coupling reaction of alkenyl tosylates or mesylates with a variety of ureas has been developed. This catalyst system boasts outstanding functional group tolerance and enables the quick synthesis of the entire series of enurea analogs via Pd-catalyzed C–N coupling reactions in excellent yields.