Palladium-catalyzed three-component reaction of ferrocenyl allenes, aryl iodides and active methylene compounds: regio- and stereoselective synthesis of (E)-alkenylferrocenes

Abstract

A concise protocol for the synthesis of (E)-alkenylferrocene derivatives based on the palladium-catalyzed three-component reaction of ferrocenyl allenes, aryl iodides and active methylene compounds was developed. This transformation exemplifies a simple method for the efficient synthesis of various mono- or bisallyl-substituted alkenylferrocenes in good yields with excellent regio- and stereoselectivities.