Immuno-driven plasmonic oligomer sensor for the ultrasensitive detection of antibiotics

Abstract

In this study, a simple plasmonic chiral sensor was facilely fabricated based on AuNP oligomers, not aggregations, which were formed by an immuno-driven assembly of two different types of gold nanoparticles. Taking advantage of the high sensitivity of circular dichroism spectroscopy and the high specificity of immuno-recognition, the developed method was used for ultratrace analysis of antibiotics in water. Using SDM as a model antibiotic, the limit of detection reached 0.014 ng mL⁻¹, which is much lower than for other methods. This sensor could be applied to monitor accurate occurrence data of antibiotics in different environments.