Issue 37, 2013
From the journal:

RSC Advances

Solid support mediated chemo and regioselective synthesis of 3H-1,5- benzodiazepines from diversely substituted α-oxo ketene dithioacetals†

Nutan Sharma,a   Tejpal Singh Chundawat,a   Subash Chandra Mohapatraa  and  Sunita Bhagat*a  

* Corresponding authors

a Organic Synthesis Research Laboratory, Department of Chemistry, A.R.S.D. College, University of Delhi, New Delhi-110021, India
E-mail: sunitabhagat28@rediffmail.com

Abstract

Solvent free, dry media supported synthesis of a series of 4-aryl/heteroaryl-2-methylthio-3H-1,5-benzodiazepines by chemo- and regioselective cyclization of substituted α-oxoketene dithioacetals with o-phenylenediamines is described. The X-ray crystallographic studies confirmed the formation of the cyclized product.

Graphical abstract: Solid support mediated chemo and regioselective synthesis of 3H-1,5- benzodiazepines from diversely substituted α-oxo ketene dithioacetals

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Article information

DOI
https://doi.org/10.1039/C3RA43347A
Article type
Communication
Submitted
29 Apr 2013
Accepted
18 Jul 2013
First published
23 Jul 2013

RSC Adv., 2013,3, 16336-16339

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Solid support mediated chemo and regioselective synthesis of 3H-1,5- benzodiazepines from diversely substituted α-oxo ketene dithioacetals

N. Sharma, T. S. Chundawat, S. C. Mohapatra and S. Bhagat, RSC Adv., 2013, 3, 16336 DOI: 10.1039/C3RA43347A

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