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Issue 40, 2013
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The regioselective Larock indole synthesis catalyzed by NHC–palladium complexes

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Abstract

The first practical and regioselective process for the synthesis of 2,3-disubstituted indoles from the reaction of o-iodoanilines or o-bromoanilines and their derivatives with symmetrical and unsymmetrical internal alkynes catalyzed by a ferrocene-functionalized N-heterocyclic carbene (NHC)–palladium complex has been developed, and the indoles were isolated in good yields with high regioselectivity.

Graphical abstract: The regioselective Larock indole synthesis catalyzed by NHC–palladium complexes

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Article information


Submitted
05 Jun 2013
Accepted
29 Jul 2013
First published
30 Jul 2013

RSC Adv., 2013,3, 18345-18350
Article type
Paper

The regioselective Larock indole synthesis catalyzed by NHC–palladium complexes

P. He, Y. Du, G. Liu, C. Cao, Y. Shi, J. Zhang and G. Pang, RSC Adv., 2013, 3, 18345
DOI: 10.1039/C3RA42788A

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