Issue 40, 2013
From the journal:

RSC Advances

One-pot fluorination and asymmetric Michael addition promoted by recyclable fluorous organocatalysts†

Wen-Bin Yi,*a   Zijuan Zhang,b   Xin Huang,b   Angela Tanner,b   Chun Caia  and  Wei Zhang*b  

* Corresponding authors

a School of Chemical Engineering, Nanjing University of Science and Technology, Xiao Ling Wei Street, Nanjing 210094, P. R. China
E-mail: yiwenbin@mail.njust.edu.cn

b Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA
E-mail: wei2.zhang@umb.edu

Abstract

A novel one-pot fluorination and asymmetric Michael addition reaction sequence promoted by recyclable fluorous bifunctional cinchona alkaloid–thiourea organocatalysts is introduced for the synthesis of α-fluoro-β-ketoesters bearing two chiral centers.

Graphical abstract: One-pot fluorination and asymmetric Michael addition promoted by recyclable fluorous organocatalysts

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Article information

DOI
https://doi.org/10.1039/C3RA42501K
Article type
Communication
Submitted
21 May 2013
Accepted
26 Jul 2013
First published
30 Jul 2013

RSC Adv., 2013,3, 18267-18270

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One-pot fluorination and asymmetric Michael addition promoted by recyclable fluorous organocatalysts

W. Yi, Z. Zhang, X. Huang, A. Tanner, C. Cai and W. Zhang, RSC Adv., 2013, 3, 18267 DOI: 10.1039/C3RA42501K

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