Issue 38, 2013
From the journal:

RSC Advances

Assembly–disassembly driven “off–on” fluorescent perylene bisimide probes for detecting and tracking of proteins in living cells†

Fuli Bo,a   Baoxiang Gao,*a   Wenfeng Duan,a   Hongxia Li,a   Hongmei Liua  and  Qianqian Baia  

* Corresponding authors

a Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Hebei University), Ministry of Education; Key Laboratory of Analytical Science and Technology of Hebei Province; College of Chemistry and Environmental Science, Hebei University, Baoding, P. R. China
E-mail: bxgao@hbu.edu.cn
Fax: +86 3125079317

Abstract

We have developed an assembly–disassembly driven “off–on” fluorescent bioprobe based on amphiphilic perylene bisimide. In aqueous solutions, the amphiphilic probes can form self-assembled nanostructures with quenched fluorescence. These probes could then be disassembled by the binding of the probes to the targeted proteins, and the disassembly process leads to a 23-fold enhancement in fluorescence intensity. Amphiphilic perylene bisimides could be used as probes for the detection and tracking of targeted proteins under live cell conditions.

Graphical abstract: Assembly–disassembly driven “off–on” fluorescent perylene bisimide probes for detecting and tracking of proteins in living cells

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Article information

DOI
https://doi.org/10.1039/C3RA42284D
Article type
Communication
Submitted
09 May 2013
Accepted
22 Jul 2013
First published
23 Jul 2013

RSC Adv., 2013,3, 17007-17010

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Assembly–disassembly driven “off–on” fluorescent perylene bisimide probes for detecting and tracking of proteins in living cells

F. Bo, B. Gao, W. Duan, H. Li, H. Liu and Q. Bai, RSC Adv., 2013, 3, 17007 DOI: 10.1039/C3RA42284D

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