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Issue 48, 2013
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Cysteamine hydrochloride protected carbon dots as a vehicle for the efficient release of the anti-schizophrenic drug haloperidol

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Abstract

The use of phenylalanine derived non-toxic carbon dots (C-dots) as a vehicle for the delivery of widely used anti-psychotic drug haloperidol (HaLO) is described in the present research work. The C-dots were found to have remarkable optical properties and to exhibit bright green fluorescence under UV light (λex = 365 nm). The UV-Vis spectrum of the C-dots exhibits peaks at 232 and 276 nm confirming their synthesis in solution. The size of the C-dots was found to be in the range of 5–10 nm, as confirmed by Field Emission Scanning Electron Microscopy (FE-SEM). Cysteamine hydrochloride (CysHCl) was used as a non-toxic linker to functionalize the purified C-dots before grafting HaLO on the surface to facilitate the controlled release under physiological conditions. A constant release of HaLO was achieved for more than 40 h, which followed the Hixson–Crowell model under standardized conditions. The C-dot–CysHCl–HaLO conjugate was found to have a much higher compatibility with MDCK cells at pH 7.2 in comparison to bare HaLO.

Graphical abstract: Cysteamine hydrochloride protected carbon dots as a vehicle for the efficient release of the anti-schizophrenic drug haloperidol

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Supplementary files

Article information


Submitted
30 Apr 2013
Accepted
08 Oct 2013
First published
09 Oct 2013

RSC Adv., 2013,3, 26290-26296
Article type
Paper

Cysteamine hydrochloride protected carbon dots as a vehicle for the efficient release of the anti-schizophrenic drug haloperidol

S. Pandey, A. Mewada, M. Thakur, A. Tank and M. Sharon, RSC Adv., 2013, 3, 26290
DOI: 10.1039/C3RA42139B

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