Issue 37, 2013
From the journal:

RSC Advances

Piperolein B, isopiperolein B and piperamide C9:1(8E): total synthesis and cytotoxicities†

Francis Kayamba,‡a   Christopher Dunnill,‡a   David J. Hamnett,a   Arantxa Rodríguez,a   Nikolaos T. Georgopoulos§*a  and  Wesley J. Moran§*a  

* Corresponding authors

a Department of Chemical & Biological Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield, UK
E-mail: w.j.moran@hud.ac.uk, n.georgopoulos@hud.ac.uk
Fax: +44 (0)1484 47 2182

Abstract

Total syntheses of the reported structures of piperolein B, isopiperolein B and piperamide C9:1(8E) have been achieved. The analytical data reported for piperolein B and piperamide C9:1(8E) match the synthetic values, however those for isopiperolein B do not. The cytotoxicities of these three structurally similar compounds against cancer cell lines of different tissue origins were evaluated and the results indicated that these compounds show differential effects on cancer cell viability.

Graphical abstract: Piperolein B, isopiperolein B and piperamide C9:1(8E): total synthesis and cytotoxicities

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3RA42060D
Article type
Paper
Submitted
26 Apr 2013
Accepted
15 Jul 2013
First published
15 Jul 2013
This article is Open Access
Creative Commons BY license

RSC Adv., 2013,3, 16681-16685

Permissions

Request permissions

Piperolein B, isopiperolein B and piperamide C9:1(8E): total synthesis and cytotoxicities

F. Kayamba, C. Dunnill, D. J. Hamnett, A. Rodríguez, N. T. Georgopoulos and W. J. Moran, RSC Adv., 2013, 3, 16681 DOI: 10.1039/C3RA42060D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements