Issue 36, 2013
From the journal:

RSC Advances

A novel multicomponent microwave-assisted synthesis of 5-aza-adenines†

Anton V. Dolzhenko,*ab   Svetlana A. Kalininac  and  Dmitrii V. Kalininc  

* Corresponding authors

a School of Pharmacy, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, Selangor 46150, Malaysia
E-mail: anton.dolzhenko@monash.edu
Fax: +603 551406207
Tel: +603 55145867

b School of Pharmacy, Curtin Health Innovation Research Institute, Curtin University, GPO Box U1987 Perth, Western Australia 6845, Australia
E-mail: anton.dolzhenko@curtin.edu.au

c Perm State Pharmaceutical Academy, 2 Polevaya Street, Perm 614990, Russian Federation

Abstract

A novel multicomponent strategy for the efficient synthesis of 5-aza-adenines was developed. 5-Aza-adenines were prepared in a one-pot fashion from 5-amino-1,2,4-triazoles, cyanamide and triethyl orthoformate under microwave irradiation. The operational simplicity, efficiency and accessibility of this method make it highly attractive for the generation of bioactive compound libraries.

Graphical abstract: A novel multicomponent microwave-assisted synthesis of 5-aza-adenines

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Article information

DOI
https://doi.org/10.1039/C3RA41932K
Article type
Paper
Submitted
19 Apr 2013
Accepted
21 Jun 2013
First published
28 Jun 2013

RSC Adv., 2013,3, 15850-15855

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A novel multicomponent microwave-assisted synthesis of 5-aza-adenines

A. V. Dolzhenko, S. A. Kalinina and D. V. Kalinin, RSC Adv., 2013, 3, 15850 DOI: 10.1039/C3RA41932K

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