Issue 30, 2013
From the journal:

RSC Advances

A selective turn-on fluorescence strategy for the detection of 5-hydroxymethyl-2′-deoxycytidine†

Shengyong Yan,‡a   Xiaowei Xu,‡a   Pu Guo,a   Jianlin Hu,a   Changcheng Wang,a   Rong Huang,a   Xiaocheng Weng,a   Yuhao Dua  and  Xiang Zhou*ab  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan, Hubei, P. R. of China
E-mail: xzhou@whu.edu.cn
Fax: 96-27-87336380
Tel: 86-27-61056559

b State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, P. R. of China

Abstract

A new type of 1,3-O,N-heterocycle, including two fluorescent derivatives, has been synthesised by the reaction of the hydroxyl and amine groups of 5-hydroxymethyl-2′-deoxycytidine (hmC). This reactivity is shown to enable the selective recognition of hmC over other natural nucleotides in aqueous buffer.

Graphical abstract: A selective turn-on fluorescence strategy for the detection of 5-hydroxymethyl-2′-deoxycytidine

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Article information

DOI
https://doi.org/10.1039/C3RA41669K
Article type
Communication
Submitted
10 Apr 2013
Accepted
03 Jun 2013
First published
04 Jun 2013

RSC Adv., 2013,3, 12066-12068

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A selective turn-on fluorescence strategy for the detection of 5-hydroxymethyl-2′-deoxycytidine

S. Yan, X. Xu, P. Guo, J. Hu, C. Wang, R. Huang, X. Weng, Y. Du and X. Zhou, RSC Adv., 2013, 3, 12066 DOI: 10.1039/C3RA41669K

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