Issue 34, 2013
From the journal:

RSC Advances

A distinct novel approach for the synthesis of 3-indolyl-methanamines starting from indoles, aldehydes and nitrobenzenes in water†‡

Biswanath Das,*a   Jayprakash Narayan Kumar,a   Avula Satya Kumar,a   Gandham Satyalakshmia  and  Digambar Balaji Shindea  

* Corresponding authors

a Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 607, India
E-mail: biswanathdas@yahoo.com
Fax: +91-40-27193198

Abstract

3-Indolyl-methanamines have efficiently been synthesized by the treatment of indoles with aldehydes and nitrobenzenes using indium in aqueous HCl at room temperature. The products are formed in excellent yields (91–98%) within a short period of time (30–45 min). Bisindolyl methanes have not been obtained under the present reaction conditions.

Graphical abstract: A distinct novel approach for the synthesis of 3-indolyl-methanamines starting from indoles, aldehydes and nitrobenzenes in water

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Article information

DOI
https://doi.org/10.1039/C3RA41131A
Article type
Paper
Submitted
08 Mar 2013
Accepted
10 Jun 2013
First published
01 Jul 2013

RSC Adv., 2013,3, 14308-14311

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A distinct novel approach for the synthesis of 3-indolyl-methanamines starting from indoles, aldehydes and nitrobenzenes in water

B. Das, J. N. Kumar, A. S. Kumar, G. Satyalakshmi and D. B. Shinde, RSC Adv., 2013, 3, 14308 DOI: 10.1039/C3RA41131A

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