Total synthesis of dysiherbaine and neodysiherbaine A

Abstract

Dysiherbaine and neodysiherbaine are two functionalized glutamate amino acids of marine origin presenting an original bicyclic pyranofuran core. Moreover, they display powerful neuropharmacological activities as CNS agents. Combination of their unique chemical structures with their pharmacological profiles makes these compounds attractive targets both for the ‘synthetic' and the ‘biological' communities. This review describes the different synthetic approaches published during the period 2000–2012.