Issue 25, 2013
From the journal:

RSC Advances

Practical synthesis of fingolimod from diethyl acetamidomalonate†‡

Bhaskar Kandagatla,a   Vetukuri Venkata Naga Kali Vara Prasada Raju,b   Narayana Sravan Kumar,a   Ganta Madhusudhan Reddy,b   Katkam Srinivas,b   Javed Iqbal,a   Rakeshwar Bandichhorb  and  Srinivas Oruganti*a  

* Corresponding authors

a Center for Process Research & Innovation, Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India
E-mail: soruganti@drils.org

b API R&D, IPDO-Innovation Plaza, Dr Reddy's Laboratories Ltd, Bachupally, Qutubullapur, Hyderabad 500 072, India

Abstract

A facile six-step synthesis of fingolimod, starting from readily available and inexpensive starting material diethyl acetamidomalonate, in very good yield is demonstrated.

Graphical abstract: Practical synthesis of fingolimod from diethyl acetamidomalonate

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Article information

DOI
https://doi.org/10.1039/C3RA40894A
Article type
Communication
Submitted
21 Feb 2013
Accepted
03 May 2013
First published
07 May 2013

RSC Adv., 2013,3, 9687-9689

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Practical synthesis of fingolimod from diethyl acetamidomalonate

B. Kandagatla, V. V. N. K. V. Prasada Raju, N. S. Kumar, G. M. Reddy, K. Srinivas, J. Iqbal, R. Bandichhor and S. Oruganti, RSC Adv., 2013, 3, 9687 DOI: 10.1039/C3RA40894A

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