One-pot synthesis of carbon-decorated FePt nanoparticles and their application for label-free electrochemical impedance sensing of DNA hybridization

Abstract

Highly monodispersive FePt nanoparticles (NPs) assembled on carbon nanotubes (CNTs) or graphene oxide (GO) surfaces to form carbon-decorated FePt nanocomposites (FePt–CNTs and FePt–GO) were successfully obtained via a one-pot modified polyol protocol. Using the as-prepared nanocomposites, a novel, ultra-high-resolution electrochemical impedance DNA biosensor for the enhanced detection of the PML–RARA fusion gene in acute promyelocytic leukemia was obtained. The detection limit is up to 10⁻¹³ mol L⁻¹ for FePt–CNT-modified electrodes and 10⁻¹⁴ mol L⁻¹ for FePt–GO-modified electrodes, respectively. This work proposed a simple polyol strategy to synthesize carbon-decorated FePt nanocomposites and opened up a new direction in the application of FePt for biosensing.