Issue 10, 2013

An efficient stereo-controlled synthesis of bis-pyrimido-[4,5-d]-pyrimidine derivatives via aza-Diels–Alder methodology and their preliminary bioactivity

Abstract

The one-pot synthesis of novel fused bis-pyrimido-[4,5-d]pyrimidine derivatives by a three-component reaction of 6-[(dimethylamino)methylene]1,3-dimethylaminouracil, terephthalaldehyde and amino derivatives has been depicted. The structures of the compounds were established by studying various spectroscopic methods and single-crystal X-ray crystallography. The long range W-coupling constant in 1H-NMR spectra is an infrequent example, where our synthesized novel compounds show such a distinctive constant. The synthetic strategy provides an efficient way to synthesise bis-pyrimidine-fused heterocycles that can be explored for further potential pharmaceutical or biological activities.

Graphical abstract: An efficient stereo-controlled synthesis of bis-pyrimido-[4,5-d]-pyrimidine derivatives via aza-Diels–Alder methodology and their preliminary bioactivity

Supplementary files

Article information

Article type
Paper
Submitted
09 Sep 2012
Accepted
30 Oct 2012
First published
14 Jan 2013

RSC Adv., 2013,3, 3407-3413

An efficient stereo-controlled synthesis of bis-pyrimido-[4,5-d]-pyrimidine derivatives via aza-Diels–Alder methodology and their preliminary bioactivity

S. Das, A. J. Thakur, T. Medhi and B. Das, RSC Adv., 2013, 3, 3407 DOI: 10.1039/C3RA22089C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements