Issue 14, 2013

Novel diastereoselective synthesis of spiropyrrolidine-oxindole derivatives as anti-breast cancer agents

Abstract

A novel class of diastereoselective spiropyrrolidine-oxindole derivatives were synthesized from isatin, 2-phenylthiazolidine-4-carboxylic acid and chalcone in a one-pot multicomponent reaction via 1,3-dipolar cycloaddition. The advantages of this methodology are the mild reaction conditions, high diastereoselectivity and high yield. These derivatives exhibited promising anti-cancer activity against the human breast cancer cell lines.

Graphical abstract: Novel diastereoselective synthesis of spiropyrrolidine-oxindole derivatives as anti-breast cancer agents

Supplementary files

Article information

Article type
Paper
Submitted
27 Jul 2012
Accepted
05 Dec 2012
First published
25 Jan 2013

RSC Adv., 2013,3, 4731-4735

Novel diastereoselective synthesis of spiropyrrolidine-oxindole derivatives as anti-breast cancer agents

A. Kumar, G. Gupta, S. Srivastava, A. K. Bishnoi, R. Saxena, R. Kant, R. S. Khanna, P. R. Maulik and A. Dwivedi, RSC Adv., 2013, 3, 4731 DOI: 10.1039/C3RA21595D

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