Issue 10, 2013
From the journal:

RSC Advances

Active site plasticity of a critical enzyme from Mycobacterium tuberculosis†

Sebastian Reichaua  and  Emily J. Parker*a  

* Corresponding authors

a Biomolecular Interaction Centre and Department of Chemistry, PO Box 4800, University of Canterbury, Christchurch, New Zealand
E-mail: emily.parker@canterbury.ac.nz
Fax: +64 3 364 2100
Tel: +64 3 364 2871

Abstract

3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase is an important biosynthetic enzyme in Mycobacterium tuberculosis and a potential drug target. We describe the synthesis, evaluation and docking of inhibitors with various chain lengths, which provide insight into the plasticity of the active site for inhibitor binding.

Graphical abstract: Active site plasticity of a critical enzyme from Mycobacterium tuberculosis

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Article information

DOI
https://doi.org/10.1039/C3RA00037K
Article type
Communication
Submitted
26 Oct 2012
Accepted
14 Jan 2013
First published
16 Jan 2013

RSC Adv., 2013,3, 3209-3212

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Active site plasticity of a critical enzyme from Mycobacterium tuberculosis

S. Reichau and E. J. Parker, RSC Adv., 2013, 3, 3209 DOI: 10.1039/C3RA00037K

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