Issue 9, 2013
From the journal:

RSC Advances

A non-isothiocyanate route to synthesize trisubstituted thioureas of arylamines using in situ generated dithiocarbamates†

Begur Vasanthkumar Varuna  and  Kandikere Ramaiah Prabhu*a  

* Corresponding authors

a Department of Organic chemistry, Indian Institute of Science, Bangalore, 560 012, Karnataka, India
E-mail: prabhu@orgchem.iisc.ernet.in
Fax: +91-80-23600529
Tel: +91-80-22932887

Abstract

A novel, user-friendly, and convenient method for the synthesis of trisubstituted thioureas of arylamines is presented, for the first time, using in situ generated dithiocarbamates of secondary amines. This strategy provides an excellent opportunity to access thioureas containing primary aryl amines. A non-isothiocyanate route to obtain thioureas is the advantage of this strategy, which may provide a useful route to synthesize a variety of biologically active derivatives of thioureas.

Graphical abstract: A non-isothiocyanate route to synthesize trisubstituted thioureas of arylamines using in situ generated dithiocarbamates

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Article information

DOI
https://doi.org/10.1039/C2RA23257J
Article type
Paper
Submitted
14 Sep 2012
Accepted
12 Dec 2012
First published
12 Dec 2012

RSC Adv., 2013,3, 3079-3087

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A non-isothiocyanate route to synthesize trisubstituted thioureas of arylamines using in situ generated dithiocarbamates

B. V. Varun and K. R. Prabhu, RSC Adv., 2013, 3, 3079 DOI: 10.1039/C2RA23257J

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