Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 17, 2013
Previous Article Next Article

pH and redox responsive hydrogels and nanogels made from poly(2-ethyl-2-oxazoline)

Author affiliations

Abstract

Hydrogels and nanogels made from partially hydrolyzed poly(2-ethyl-2-oxazoline) (PEtOx) were prepared by two different processes. First, both hydrogels and nanogels were made in dilute media in the presence of 1,6-hexanediol di-glycidyl ether (1) as the cross-linker. Alternatively, the PEtOx precursor was engineered into nanogels by an inverse w/o emulsion process. In the latter case, in addition to cross-linker 1, a cleavable cross-linker homologue (2), namely 1,6-hydroxyethyl disulfide-bis-di-glycidyl ether, was used to produce cleavable nanogels. The pH-responsiveness of all cross-linked PEtOx derivatives was demonstrated in an acidic environment, owing to the protonation of residual ethylene imine groups and/or tertiary amines formed during the cross-linking reaction. Nanogels derived from cross-linker 2 could readily be cleaved under a reducing environment, due to the presence of disulfide linkages at the cross-linking points.

Graphical abstract: pH and redox responsive hydrogels and nanogels made from poly(2-ethyl-2-oxazoline)

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 May 2013, accepted on 21 Jun 2013 and first published on 24 Jun 2013


Article type: Paper
DOI: 10.1039/C3PY00685A
Citation: Polym. Chem., 2013,4, 4801-4808

  •   Request permissions

    pH and redox responsive hydrogels and nanogels made from poly(2-ethyl-2-oxazoline)

    C. Legros, M. De Pauw-Gillet, K. C. Tam, S. Lecommmandoux and D. Taton, Polym. Chem., 2013, 4, 4801
    DOI: 10.1039/C3PY00685A

Search articles by author

Spotlight

Advertisements