Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 17, 2013
Previous Article Next Article

pH and redox responsive hydrogels and nanogels made from poly(2-ethyl-2-oxazoline)

Author affiliations

Abstract

Hydrogels and nanogels made from partially hydrolyzed poly(2-ethyl-2-oxazoline) (PEtOx) were prepared by two different processes. First, both hydrogels and nanogels were made in dilute media in the presence of 1,6-hexanediol di-glycidyl ether (1) as the cross-linker. Alternatively, the PEtOx precursor was engineered into nanogels by an inverse w/o emulsion process. In the latter case, in addition to cross-linker 1, a cleavable cross-linker homologue (2), namely 1,6-hydroxyethyl disulfide-bis-di-glycidyl ether, was used to produce cleavable nanogels. The pH-responsiveness of all cross-linked PEtOx derivatives was demonstrated in an acidic environment, owing to the protonation of residual ethylene imine groups and/or tertiary amines formed during the cross-linking reaction. Nanogels derived from cross-linker 2 could readily be cleaved under a reducing environment, due to the presence of disulfide linkages at the cross-linking points.

Graphical abstract: pH and redox responsive hydrogels and nanogels made from poly(2-ethyl-2-oxazoline)

Back to tab navigation

Supplementary files

Article information


Submitted
27 May 2013
Accepted
21 Jun 2013
First published
24 Jun 2013

Polym. Chem., 2013,4, 4801-4808
Article type
Paper

pH and redox responsive hydrogels and nanogels made from poly(2-ethyl-2-oxazoline)

C. Legros, M. De Pauw-Gillet, K. C. Tam, S. Lecommmandoux and D. Taton, Polym. Chem., 2013, 4, 4801
DOI: 10.1039/C3PY00685A

Social activity

Search articles by author

Spotlight

Advertisements