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Issue 6, 2013
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Biofunctional micellar nanoparticles from peptide-b-polymer chimeras

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Abstract

We describe the precision synthesis and characterization of amphiphilic peptide-b-polymer chimeras encoding, at the molecular level, self-assembly properties and biological functions, presently cell membrane penetrating motifs (Tat peptide). Self-assembled micellar nanoparticles obtained from a series of Tat-b-poly(trimethylene carbonate) (Tat-b-PTMC) chimeras with tunable hydrophilic fractions were finely characterized in order to establish chimera–nanoparticle structure relationships. Well-defined nanoparticles with diameters ranging from 22 to 40 nm could be obtained by direct self-assembly in buffer.

Graphical abstract: Biofunctional micellar nanoparticles from peptide-b-polymer chimeras

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Article information


Submitted
27 Nov 2012
Accepted
22 Dec 2012
First published
07 Jan 2013

Polym. Chem., 2013,4, 2011-2018
Article type
Paper

Biofunctional micellar nanoparticles from peptide-b-polymer chimeras

C. Drappier, A. Wirotius, K. Bathany, E. Ibarboure, O. Condassamy, E. Garanger and S. Lecommandoux, Polym. Chem., 2013, 4, 2011
DOI: 10.1039/C2PY21044D

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