Issue 16, 2013
From the journal:

Polymer Chemistry

Ring-opening polymerization of bile acidmacrocycles by Candida antarctica lipase B†

Satu Strandman,a   I-Huang Tsai,a   Robert Lortieb  and  X. X. Zhu*a  

* Corresponding authors

a Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, QC, Canada
Fax: +1-514-340-5290
Tel: +1-514-340-5172

b National Research Council, Biotechnology Research Institute, 6100 Royalmount Avenue, Montréal, QC, Canada

Abstract

Lipase-catalyzed polymerization was explored as an alternative for Ru-catalyzed ring opening metathesis polymerization in the synthesis of polyesters bearing large functional moieties as part of the main chain. The selectivity of Candida antarctica lipase B (CALB) towards the functional groups of cholic acid (CA) was demonstrated, and the obtained CA-based polymers had relatively high molar masses, rubber-like elasticity, and glass transitions close to body temperature.

Graphical abstract: Ring-opening polymerization of bile acid macrocycles by Candida antarctica lipase B

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Article information

DOI
https://doi.org/10.1039/C3PY00651D
Article type
Communication
Submitted
21 May 2013
Accepted
05 Jun 2013
First published
06 Jun 2013

Polym. Chem., 2013,4, 4312-4316

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Ring-opening polymerization of bile acid macrocycles by Candida antarctica lipase B

S. Strandman, I. Tsai, R. Lortie and X. X. Zhu, Polym. Chem., 2013, 4, 4312 DOI: 10.1039/C3PY00651D

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