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Issue 12, 2013
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Multifunctional poly(amine-ester)-type hyperbranched polymers: lipase-catalyzed green synthesis, characterization, biocompatibility, drug loading and anticancer activity

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Abstract

Hyperbranched polymers (HBPs) have attracted more and more attention because of their specially branched architecture and interesting properties. A series of novel poly(amine-ester)-type HBPs were synthesized through CALB-catalyzed polycondensation between triethanolamine (TEOA) and diesters after the optimization of reaction conditions. The precise structure including degree of branching, components percentage, and the controllable terminal structures at the outer surface were determined by FTIR, 1H NMR, 13C NMR, 2D NMR and GPC. The interesting multifunctionality displayed by the poly(amine-ester)-type HBPs was investigated. These HBPs could be degraded efficiently under the catalysis of lipase in weak acid buffer. The amphiphilic HBPs with hydroxyl terminals were able to form multimolecular micelles with 250–400 nm diameter, and 0.042 g L−1 CMC. They were nontoxic to COS-7 cells, while they could effectively inhibit the growth of cancer cells HepG2 with IC50 of 130 μg mL−1 after an anticancer drug was encapsulated within the micelles. All these results indicated the prepared poly(amine-ester)-type HBPs can serve as multifunctional biomaterials for biomedical applications.

Graphical abstract: Multifunctional poly(amine-ester)-type hyperbranched polymers: lipase-catalyzed green synthesis, characterization, biocompatibility, drug loading and anticancer activity

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Article information


Submitted
30 Jan 2013
Accepted
21 Mar 2013
First published
22 Mar 2013

Polym. Chem., 2013,4, 3480-3490
Article type
Paper

Multifunctional poly(amine-ester)-type hyperbranched polymers: lipase-catalyzed green synthesis, characterization, biocompatibility, drug loading and anticancer activity

F. Xu, J. Zhong, X. Qian, Y. Li, X. Lin and Q. Wu, Polym. Chem., 2013, 4, 3480
DOI: 10.1039/C3PY00156C

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