Issue 10, 2013
From the journal:

Polymer Chemistry

Pluronic L61 as a long-circulating modifier for enhanced liposomal delivery of cancer drugs†

Ye Wang,ab   Ergang Liu,b   Xiaoyi Sun,c   Pengyu Huang,a   Hao Long,a   Hua Wang,d   Xin Yu,a   Caihong Zhenge  and  Yongzhuo Huang*bf  

* Corresponding authors

a Zhejiang-California International Nanosystems Institute Molecular Imaging Platform, Zhejiang University, 268 Kaixuan Rd, Hangzhou 310029, China

b Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Hai-ke Rd, Shanghai 201203, China
E-mail: yzhuang@simm.ac.cn
Fax: +86 21 2023-1981
Tel: +86 21 2023-1000 extn 1401

c Pharmacy Department, City College, Zhejiang Universtiy, 51 Huzhou St, Hangzhou 310015, China

d Analysis and Testing Center, Zhejiang University, 268 Kaixuan Rd, Hangzhou 310029, China

e Women’s Hospital, School of Medicine, Zhejiang University, 1 Xueshi Rd, Hangzhou 310006, China

f Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA (Fudan University), Shanghai 201203, China

Abstract

Pluronic copolymer L61 was found to possess a stealth function for liposomal drug delivery, comparing favorably to PEG. The liposomes modified with 0.1% L61 (w/w) were long-circulating, and preferentially accumulated in the tumor site. The paclitaxel-loaded L61-liposomes with a single injection dose could successfully arrest the tumor growth, lasting for five days, and displayed better treatment outcomes compared to the non-modified liposomes and even the PEGylated liposomes.

Graphical abstract: Pluronic L61 as a long-circulating modifier for enhanced liposomal delivery of cancer drugs

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Article information

DOI
https://doi.org/10.1039/C3PY00042G
Article type
Communication
Submitted
09 Jan 2013
Accepted
26 Mar 2013
First published
27 Mar 2013

Polym. Chem., 2013,4, 2958-2962

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Pluronic L61 as a long-circulating modifier for enhanced liposomal delivery of cancer drugs

Y. Wang, E. Liu, X. Sun, P. Huang, H. Long, H. Wang, X. Yu, C. Zheng and Y. Huang, Polym. Chem., 2013, 4, 2958 DOI: 10.1039/C3PY00042G

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