Issue 2, 2013
From the journal:

Polymer Chemistry

Antibacterial vesicles by direct dissolution of a block copolymer in water†

Cong Zhang,a   Yunqing Zhu,a   Chuncai Zhou,a   Weizhong Yuan*a  and  Jianzhong Du*a  

* Corresponding authors

a School of Materials Science and Engineering, Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Tongji University, 4800 Caoan Road, Shanghai 201804, People's Republic of China
E-mail: jzdu@tongji.edu.cn
Fax: +86-21-6958-4723
Tel: +86-21-6958-0239

Abstract

A novel thermo- and pH-responsive antimicrobial diblock copolymer has been synthesized and directly dissolved in water to form polymer vesicles upon simply raising the temperature. Compared to individual polymer chains, polymer vesicles exhibit much better antimicrobial efficacy against both Gram-negative and Gram-positive bacteria under physiological conditions with neither quaternary ammonium moieties nor the loading of any external antibiotics as a result of their increased local concentration of cationic charge.

Graphical abstract: Antibacterial vesicles by direct dissolution of a block copolymer in water

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Article information

DOI
https://doi.org/10.1039/C2PY20719B
Article type
Communication
Submitted
06 Sep 2012
Accepted
23 Sep 2012
First published
25 Sep 2012

Polym. Chem., 2013,4, 255-259

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Antibacterial vesicles by direct dissolution of a block copolymer in water

C. Zhang, Y. Zhu, C. Zhou, W. Yuan and J. Du, Polym. Chem., 2013, 4, 255 DOI: 10.1039/C2PY20719B

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