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Issue 37, 2013
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Copper(ii)-catalyzed trifluoromethylation of N-aryl imines

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Methods for imine trifluoromethylation are of great importance because amines with trifluoromethylated stereogenic centers are useful building blocks for synthetic chemistry and drug discovery. Herein, we describe a new copper(II)-catalyzed imine trifluoromethylation method without the use of Lewis base activators, presumably through cooperative activation.

Graphical abstract: Copper(ii)-catalyzed trifluoromethylation of N-aryl imines

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Article information

20 Jun 2013
24 Jul 2013
First published
24 Jul 2013

Org. Biomol. Chem., 2013,11, 6242-6245
Article type

Copper(II)-catalyzed trifluoromethylation of N-aryl imines

Y. Zhang, J. Liu and H. Xu, Org. Biomol. Chem., 2013, 11, 6242
DOI: 10.1039/C3OB41283K

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