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Issue 32, 2013
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A fluorogenic assay for screening Sirt6 modulators

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Abstract

A fluorogenic high-throughput assay suitable for screening Sirt6 modulators is developed based on the recently discovered efficient activity of Sirt6 to hydrolyze myristoyl lysine. Sirt6 modulators will be useful in investigating the function of Sirt6 and protein lysine fatty acylation.

Graphical abstract: A fluorogenic assay for screening Sirt6 modulators

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Supplementary files

Article information


Submitted
31 May 2013
Accepted
25 Jun 2013
First published
25 Jun 2013

Org. Biomol. Chem., 2013,11, 5213-5216
Article type
Communication

A fluorogenic assay for screening Sirt6 modulators

J. Hu, B. He, S. Bhargava and H. Lin, Org. Biomol. Chem., 2013, 11, 5213
DOI: 10.1039/C3OB41138A

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