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Issue 27, 2013
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CLIP-HSQMBC: easy measurement of small proton–carbon coupling constants in organic molecules

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Abstract

A user-friendly 2D NMR approach denoted as CLIP-HSQMBC is proposed for the very easy, direct and accurate measurement of long-range proton–carbon coupling constants in organic molecules and natural products. The J value can be extracted directly from the analysis of resolved in-phase 1H multiplets that show an additional splitting arising from the proton–carbon coupling. In cases of unresolved peaks, a simple fitting analysis using the internal satellite lines as a reference is performed. Addition of a spin-lock period results in a CLIP-HSQMBC-TOCSY experiment that is suitable for the measurement of very small coupling values or to observe correlations from overlapped resonances.

Graphical abstract: CLIP-HSQMBC: easy measurement of small proton–carbon coupling constants in organic molecules

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Publication details

The article was received on 04 Apr 2013, accepted on 09 May 2013 and first published on 10 May 2013


Article type: Paper
DOI: 10.1039/C3OB40675J
Org. Biomol. Chem., 2013,11, 4473-4478

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    CLIP-HSQMBC: easy measurement of small proton–carbon coupling constants in organic molecules

    J. Saurí, T. Parella and J. F. Espinosa, Org. Biomol. Chem., 2013, 11, 4473
    DOI: 10.1039/C3OB40675J

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