Jump to main content
Jump to site search

Issue 30, 2013
Previous Article Next Article

A divergent approach to the synthesis of simplexides and congeners via a late-stage olefin cross-metathesis reaction

Author affiliations

Abstract

Simplexides constitute a unique group of immunosuppressive glycolipids that demonstrate antiproliferative activities against activated T-cell lymphocytes via a unique non-cytotoxic inhibition. To investigate the structure–activity relationship of the varied long-chain secondary alcohols on simplexides, we developed an efficient and divergent route to the synthesis of simplexides and congeners, taking advantage of a late-stage olefin cross-metathesis reaction.

Graphical abstract: A divergent approach to the synthesis of simplexides and congeners via a late-stage olefin cross-metathesis reaction

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Mar 2013, accepted on 31 May 2013 and first published on 03 Jun 2013


Article type: Paper
DOI: 10.1039/C3OB40552D
Citation: Org. Biomol. Chem., 2013,11, 4971-4974
  •   Request permissions

    A divergent approach to the synthesis of simplexides and congeners via a late-stage olefin cross-metathesis reaction

    J. Li, W. Li and B. Yu, Org. Biomol. Chem., 2013, 11, 4971
    DOI: 10.1039/C3OB40552D

Search articles by author

Spotlight

Advertisements