Jump to main content
Jump to site search

Issue 20, 2013
Previous Article Next Article

Caged retinoids as photoinducible activators: implications for cell differentiation and neurite outgrowth

Author affiliations

Abstract

Aiming to control neurite formation and navigate the axonal growth by an extrinsic guidance, we report on the design, synthesis and biological evaluation of caged retinoids. Agonists of RARβ have been temporarily blocked either by the [(α-methyl-2-nitropiperonyl)oxy]carbonyl (MeNPOC) group or by immobilization using nitrocatechol linkers on TiO2 particles. Release on demand has been achieved by release under UV irradiation, leading to the biologically active compounds, which have been shown to induce neuronal differentiation and neurite outgrowth.

Graphical abstract: Caged retinoids as photoinducible activators: implications for cell differentiation and neurite outgrowth

Back to tab navigation

Supplementary files

Publication details

The article was received on 18 Jan 2013, accepted on 14 Mar 2013 and first published on 14 Mar 2013


Article type: Paper
DOI: 10.1039/C3OB40106E
Citation: Org. Biomol. Chem., 2013,11, 3314-3321
  •   Request permissions

    Caged retinoids as photoinducible activators: implications for cell differentiation and neurite outgrowth

    J. Hoecker, R. Liffert, P. Burch, R. Wehlauch and K. Gademann, Org. Biomol. Chem., 2013, 11, 3314
    DOI: 10.1039/C3OB40106E

Search articles by author

Spotlight

Advertisements