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Issue 14, 2013
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Cube-octameric silsesquioxane-mediated cargo peptide delivery into living cancer cells

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Abstract

Cube octameric silsesquioxanes (COSS) are among the smallest nanoparticles known to date with a diameter of only 0.7 nm. We describe a COSS-based delivery system which allows for the drug targeting in human cells. It comprises a siloxane core with seven pendant aminopropyl groups and a fluorescently labeled peptidic ligand attached to one cage corner via a reversible disulfide bond to ensure its intracellular release. Bimodal amplitude-modulated atomic force microscopy (AFM) experiments revealed the formation of dendritic COSS structures by a self-assembly of single particles on negatively charged surfaces. Nuclear targeting was demonstrated in HeLa cells by selective binding of released p21Cip1/Waf1-derived cargo peptide to PCNA, a protein involved in DNA replication and repair.

Graphical abstract: Cube-octameric silsesquioxane-mediated cargo peptide delivery into living cancer cells

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Publication details

The article was received on 14 Sep 2012, accepted on 06 Dec 2012 and first published on 06 Dec 2012


Article type: Paper
DOI: 10.1039/C2OB26808F
Org. Biomol. Chem., 2013,11, 2258-2265

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    Cube-octameric silsesquioxane-mediated cargo peptide delivery into living cancer cells

    S. Hörner, S. Fabritz, H. D. Herce, O. Avrutina, C. Dietz, R. W. Stark, M. C. Cardoso and H. Kolmar, Org. Biomol. Chem., 2013, 11, 2258
    DOI: 10.1039/C2OB26808F

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