Issue 48, 2013

An organocatalytic highly efficient approach to the direct synthesis of substituted carbazoles in water

Abstract

A simple, mild, green, catalytic and general procedure for the direct synthesis of highly functionalized 1-methoxycarbonyl-2-aryl/alkyl-3-nitro-9H-carbazoles has been achieved in water medium via a one-pot domino Michael–Henry/aromatization reaction of methyl 2-(3-formyl-1H-indol-2-yl)acetates with aryl/alky-substituted β-nitroolefins under air using DABCO (30 mol%) as an organocatalyst. In addition, the bench scale synthesis can be performed without using toxic organic solvents and a biologically important new fused carbazole has been prepared.

Graphical abstract: An organocatalytic highly efficient approach to the direct synthesis of substituted carbazoles in water

Supplementary files

Article information

Article type
Paper
Submitted
11 Oct 2013
Accepted
17 Oct 2013
First published
17 Oct 2013

Org. Biomol. Chem., 2013,11, 8410-8418

An organocatalytic highly efficient approach to the direct synthesis of substituted carbazoles in water

P. K. Jaiswal, S. Biswas, S. Singh and S. Samanta, Org. Biomol. Chem., 2013, 11, 8410 DOI: 10.1039/C3OB42034E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements