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Issue 43, 2013
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The stereochemical course of tricho-acorenol biosynthesis

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Abstract

The biosynthesis of tricho-acorenol in Trichoderma harzianum was investigated by feeding stereospecifically deuterated mevalonolactone isotopomers, followed by a detailed GC/MS analysis of the incorporation of labelling. The results establish a highly stereospecific hydride migration and antarafacial attack of water in the terminal step towards tricho-acorenol.

Graphical abstract: The stereochemical course of tricho-acorenol biosynthesis

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Article information


Submitted
28 Aug 2013
Accepted
17 Sep 2013
First published
02 Oct 2013

Org. Biomol. Chem., 2013,11, 7447-7450
Article type
Communication

The stereochemical course of tricho-acorenol biosynthesis

C. A. Citron and J. S. Dickschat, Org. Biomol. Chem., 2013, 11, 7447
DOI: 10.1039/C3OB41755G

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